The breakdown products of tetracyclines are toxic and can cause Fanconi syndrome, a potentially fatal disease affecting proximal tubular function in the nephrons of the kidney.
22.
This results in renal Fanconi syndrome, and similar loss in other tissues can account for the short stature, retinopathy, and other features of the disease.
23.
In Hartnup disease, urinary excretion of proline, hydroxyproline, and arginine remains unchanged, differentiating it from other causes of generalized aminoaciduria, such as Fanconi syndrome.
24.
Among 78 live dogs in the 2004 UKC survey, the most common health issues noted by owners were dermatologic and urologic ( urologic issues in Basenjis can be signs of Fanconi syndrome ).
25.
Steve Gonto, M . M . Sc ., Ph . D ., has a'Fanconi Disease Management Protocol for Veterinarians'that is commonly used by many veterinarians with Fanconi syndrome afflicted dogs.
26.
Fanconi syndrome occurs when the function of cells in renal tubules are impaired, leading to abnormal amounts of carbohydrates and amino acids in the urine, excessive urination, and low blood levels of potassium and phosphates.
27.
The OFA offers DNA certification for canine degenerative myelopathy, neuronal ceroid lipofuscinosis for American Bulldogs, Fanconi syndrome for Basenjis and Neonatal encephalopathy with seizures for Standard Poodles through an exclusive agreement with the University of Missouri.
28.
Clinical features of tenofovir-induced Fanconi syndrome include glycosuria in the setting of normal serum glucose levels, phosphate wasting with hypophosphatemia, proteinuria ( usually mild ), acidosis, and hypokalemia, with or without acute renal failure.
29.
The nucleoside analogs acyclovir ( ACV ), zidovudine ( AZT ), didanosine ( ddI ), zalcitabine ( ddC ), lamivudine ( 3TC ), stavudine ( d4T ), trifluridine, didenosine, abacavir, adefovir, cidofovir and tenofovir has been associated with Fanconi syndrome.
30.
The distal intercalated cells function normally, so the acidemia is less severe than dRTA and the urine can acidify to a pH of less than 5.3 . pRTA also has several causes, and may occasionally be present as a solitary defect, but is usually associated with a more generalised dysfunction of the proximal tubular cells called Fanconi syndrome where there is also phosphaturia, glycosuria, aminoaciduria, uricosuria and tubular proteinuria.
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