In prostate cancer a frameshift mutation changes the open reading frame ( ORF ) and prevents apoptosis from occurring.
22.
During testing of coding regions to identify mutations, 116 genetic variants were discovered, including 61 frameshift mutations.
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It may be interesting to touch on how frameshift mutation rates can vary based on positioning within the genome.
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A frameshift mutation will in general cause the reading of the codons after the mutation to code for different amino acids.
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The frameshift mutations lead to an early stop codon which is known to play a role in the disease in infants.
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The effects of neighboring bases and secondary structure to detect the frequency of frameshift mutations has been investigated in depth using fluorescence.
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This could use disablement detection, which looks for nonsense or frameshift mutations that would truncate or collapse an otherwise functional coding sequence.
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Reverse transcriptase, as opposed to RNA Polymerase II, is thought to be a stronger cause of the occurrence of frameshift mutations.
29.
Experiments can be run to determine the frequency of the frameshift mutation by adding or removing a pre-set number of nucleotides.
30.
The other three are missense mutations and frameshift mutations, which lead to a shortening of amino acid sequence in the C terminus.
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