They concluded gossypol provided reliable contraception, could be taken orally as a tablet, and did not upset men's balance of hormones.
22.
Gossypol was one of the many substances found in all parts of the cotton plant and it was described by the scientists as'poisonous pigment '.
23.
In the mid-1990s, the Brazilian pharmaceutical company Hebron announced plans to market a low-dose gossypol pill called Nofertil, but the pill never came to market.
24.
In addition to the other side effects, the WHO researchers were concerned about gossypol's toxicity : the toxic dose in primates is less than 10 times the contraceptive dose.
25.
However, some specific kinds may be toxic, and are rather used as fertilizer, for example cottonseed contains a toxic pigment, gossypol, that must be removed before processing.
26.
Chinese scientists thought they had found an answer in the 1970s with gossypol, the active ingredient derived from cottonseed oil, after they realized that poor rural families who cooked with it had lower birth rates.
27.
This report effectively ended further studies of gossypol as a temporary contraceptive, but research into using it as an alternative to vasectomy continues in Austria, Brazil, Chile, China, the Dominican Republic, and Nigeria.
28.
He developed several such varieties that contained very high levels of gossypol ( a natural insect toxin ) and that manifested physical features ( such as glabrous leaf and stem surfaces ) that decreased their suitability for insect egg deposition.
29.
"You come to Woods Hole and sit on the sea wall and have a hero sandwich and talk about these things, and I say, ` Joan, would you take a look at gossypol's effects on cyclins ? "'
30.
Dr . Sheldon Segal of the Population Council said that in his work this summer at the Marine Biological Laboratory on the potential use of gossypol, a substance extracted from cottonseed, as a potential male contraceptive, he could call on the services of a senior Argentine specialist in electron microscopy; a young medical student from Cornell; Dr . George Langford of Dartmouth, an expert on intracellular transport methods who looked at how the substance affected sperm motion, and Joan Ruderman, a Harvard biologist.
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