21. Granulomatous tubercules eventually develop central caseous necrosis and tend to become confluent, replacing the lymphoid tissue.22. Granulomatous tubercules evolve to central caseous necrosis and tend to become confluent, replacing the lymphoid tissue.23. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease ( CGD ). 24. In fact, they are found in nearly every form of granulomatous disease, regardless of etiology. 25. If a reaction is present, it is typically granulomatous with an admixture of eosinophils and lymphocytes. 26. He was diagnosed as suffering from granulomatous pneumonitis, more commonly known as vineyard sprayer's lung. 27. There is a concentration of saliva and presumably toxin in the granulomatous reaction around the tick mouth parts. 28. In all these species, actinomycosis results in cold abscess, with granulomatous formations on the fistulised place. 29. Tolosa-Hunt syndrome is an idiopathic granulomatous disease that causes painful oculomotor ( especially sixth nerve ) palsies. 30. There are over 410 known possible defects in the PHOX enzyme complex that can lead to chronic granulomatous disease.