Studies on animals ( rats, monkeys, hamsters ) show that acidic guanidine derivatives such as ?-GPA can ameliorate hyperglycemia in animal models of noninsulin-dependent diabetes.
22.
In the original Barton publication the reaction was optimized by using a strong guanidine base, the inverse addition of the hydrazone to an iodine solution, and by exclusion of water.
23.
The leaves, roots and stem bark contain terpenoids, steroid glycosides, flavonoids, tannins, saponins, carbohydrates and the imidazopyrimidine alkaloids alchorneine, alchornidine, and several guanidine alkaloids.
24.
It was proposed that the toxicity arose from the thiourea group, and similar guanidine analogues were investigated until the discovery of cimetidine, which would become the first clinically successful H 2 antagonist.
25.
It has a nitrile group on it-- but how many pKa units would it raise ? pKa of guanidine is 1.5, so plausibly a CN group could raise it to 7?
26.
Ammonium nitrogen was shown to foster arginine and amides and lead to a large increase of free guanidine compounds, whereas in leaves nourished by nitrate as the sole source of nitrogen guanidine compounds were less prominent.
27.
Ammonium nitrogen was shown to foster arginine and amides and lead to a large increase of free guanidine compounds, whereas in leaves nourished by nitrate as the sole source of nitrogen guanidine compounds were less prominent.
28.
Agarose is a useful material for chromatography because it does not absorb biomolecules to any significant extent, has good flow properties, and can tolerate extremes of pH and ionic strength as well as high concentration of guanidine HCl.
29.
An older agent, guanidine, causes many side-effects and is not recommended . 4-Aminopyridine ( dalfampridine ), an agent related to 3, 4-aminopyridine, causes more side-effects than 3, 4-DAP and is also not recommended.
30.
The nonspecificity of Jaffe's reaction causes falsely elevated creatinine results in the presence of protein, glucose, acetoacetate, ascorbic acid, guanidine, acetone, cephalosporins, aminoglycosides ( mainly streptomycin ), ketone bodies, ?-keto acids, and other organic compounds.
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