Biotechnology drugs are generally human proteins like insulin or growth hormone that are manufactured by putting the gene for the protein into bacteria or hamster cells, then multiplying those cells in stainless steel fermentation tanks.
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Amgen, the nation's largest biotechnology company, uses conventional gene-splicing, in which it clones the human gene governing EPO production and puts it in hamster cells, which are then grown in culture to produce the drug.
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By transplanting genes from a spider into cow and hamster cells, scientists have caused those cells to produce the protein that makes spider silk, a step that could point the way to commercial production of the tough fiber.
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After providing a sample of the purified EPO to researchers at Amgen, a team there led by Fu-Kuen Lin was able to identify and patent the gene that produced EPO and was able to generate useful quantities of human EPO by using genetic engineering techniques to insert the gene into hamster cells.
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