It was withdrawn a few years later in 1961 due to a high incidence of hepatitis, and was replaced by less hepatotoxic drugs such as phenelzine and isocarboxazid.
22.
Some experts say that comfrey should be restricted to topical use, and should never be ingested, as it contains dangerous amounts of hepatotoxic pyrrolizidine alkaloids ( PAs ).
23.
"' Paracetamol "'( acetaminophen, APAP ) is converted into the hepatotoxic metabolite NAPQI via the cytochrome P450 oxidase system, mainly by the subfamily CYP2E1.
24.
Paracetamol is metabolised by the liver and is hepatotoxic; side effects are multiplied when combined with alcoholic drinks, and are very likely in stomach bleeding when high doses are taken chronically.
25.
Nitrosamines are also generally avoided in drug development as they can often be hepatotoxic, so while the combined mechanisms of action are likely to be effective, this drug also has severe risks of toxicity.
26.
They found that temulawak has anti-bacterial, anti-fungus, anti-diabetic, anti-diarrhea, anti-inflammation, anti-hepatotoxic, anti-oxydant and anti-tumor qualities.
27.
A number of scientists and medical practitioners criticized the poor quality of the reports by pointing out that most of the reported rare cases of hepatotoxicity involved patients with a history of alcohol or prescription drugs abuse or concomitant use of medicines known as potentially hepatotoxic.
28.
Some no flush types, such as inositol hexanicotinate contain convertible niacin compounds, but have little clinical efficacy in reducing cholesterol levels . Slow release varieties have higher hepatotoxic activity, hence some types of prescription niacin are not recommended due to potential harm.
29.
Around 15 % of those poisoned will die within 10 days, progressing through a comatose stage to kidney failure, liver failure, IV administration, is used in treatment of severe intoxications with hepatotoxic substances such as paracetamol to treat " Amanita phalloides " poisoning.
30.
The drug notably shows a much lower hepatotoxic potential than dimethandrolone and trestolone ( 7?-methyl-19-nortestosterone; MENT ), which may have an increased risk due to their shared C7? methyl group ( although a risk that is still significantly lower than that of 17?-alkylated AAS ).
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