For example, mutation of ZIC3 is associated with heterotaxy, that is thought to occur due to the role of ZIC3 in initial left-right symmetry formation, which involves the maintaining redistributed Nodal after the asymmetry of the embryo is initially broken.
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There is an international effort to identify genes that code for inner dynein arm proteins or proteins from other ciliary structures ( radial spokes, central apparatus, etc . ) associated with PCD . The role of DNAH5 in heterotaxy syndromes and left-right asymmetry is also under investigation.
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