The cause of Mertz's death has never been firmly established; the commonly purported theory is hypervitaminosis A ( an excessive intake of vitamin A ) from consuming the livers of the Huskies.
22.
Elevated amounts of retinyl ester ( i . e ., > 10 % of total circulating vitamin A ) in the fasting state have been used as markers for chronic hypervitaminosis A in humans.
23.
Elevated amounts of retinyl ester ( i . e ., > 10 % of total circulating vitamin A ) in the fasting state have been used as markers for chronic hypervitaminosis A in humans and monkeys.
24.
De Veer kept a diary of the voyages and in 1597 was the first person to observe and record the Novaya Zemlya effect, and the first westerner to observe hypervitaminosis A caused by consuming polar bear liver.
25.
"' Hypervitaminosis A "'refers to the toxic effects of ingesting too much preformed vitamin A . Symptoms arise as a result of altered bone metabolism and altered metabolism of other fat-soluble vitamins.
26.
High intake of provitamin carotenoids ( such as beta carotene ) from vegetables and fruits does not cause hypervitaminosis A, as conversion from carotenoids to the active form of vitamin A is regulated by the body to maintain an optimum level of the vitamin.
27.
Hypervitaminosis A can be prevented by not ingesting more than the US Institute of Medicine Daily Tolerable Upper Level of intake for Vitamin A . This level is for synthetic and natural retinol ester forms of vitamin A . Carotene forms from dietary sources are not toxic.
28.
A 1969 study by depression, dysentery and persistent skin infections indicated the men had suffered hypervitaminosis A, an excessive intake of vitamin A . This is found in unusually high quantities in the livers of Greenland Huskies, of which both Mertz and Mawson consumed large amounts.
29.
The liver of one dog contains enough vitamin A to produce the condition called Hypervitaminosis A . Mertz became incapacitated and incoherent; in an attempt to nurse him back to health, Mawson fed him most of the dog livers, which he considered more nourishing than the tough muscle tissue.
30.
Too much vitamin A in retinoid form can be harmful or fatal, resulting in what is known as hypervitaminosis A . The body converts the dimerized form, carotene, into vitamin A as it is needed, therefore high levels of carotene are not toxic compared to the ester ( animal ) forms.
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