21. Chemically, sertaconazole contains a benzothiophene ring which makes it unique from other imidazole antifungals. 22. "' Detomidine "'is an imidazole derivative and salt detomidine hydrochloride. 23. "' Nafimidone "'is an anticonvulsant drug of the imidazole class. 24. It was proposed that imidazole nucleophilic catalyst and proline effect the reaction via iminium intermediate. 25. The imidazole ring has two nitrogens. 26. Another related reaction is the reaction of formic acid with CDI to form the formylized imidazole . 27. It has a hydroxyisopropyl group connected to the imidazole ring in addition to the carboxyl group. 28. As a result, imidazole -1-sulfonyl azide has been developed as an alternative. 29. These imidazoles share the 1, 3-C 3 N 2 ring but feature varied substituents. 30. These methods are commonly categorized by which and how many bonds form to make the imidazole rings.
