21. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity.22. This protein has been reported to have inhibin -like properties, though this finding has been disputed. 23. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity.24. Sections of testicular tissue from rat revealed positive immunoreactivity against anti-inhibin intensely appeared in Leydig cells. 25. Inhibin , activin, and sex hormones do not affect genetic activity for the beta subunit production of LH.26. For women with stromal cancers, tests for hormones like estrogen, testosterone, and inhibin are sometimes helpful. 27. Inhibin acts to inhibit activin, which is a peripherally produced hormone that positively stimulates GnRH-producing cells.28. An Indian study showed a strong correlation between incidence of POF and certain variants in the inhibin alpha gene. 29. Recently, additional inhibin specific binding proteins were identified in inhibin target tissues, including pituitary and Leydig cells. 30. Recently, additional inhibin specific binding proteins were identified in inhibin target tissues, including pituitary and Leydig cells.
