It was found to depress the tonicity of coronary vessels, improve myocardial metabolism ( so that heart can sustain hypoxia better ) and also exert a positive chronotropic and inotropic effects, thereby not precipitating angina pectoris.
22.
In a 1995 study, Hapke and Strathmann reported that in dogs and rats hordenine produced a positive inotropic effect on the heart ( i . e . increased the strength of contraction ), increased systolic and diastolic blood pressure, and increased the volume of peripheral blood flow.
23.
Since this carrier enzyme (-translocator ) uses the Na gradient generated by the-pump to remove from the intracellular space, slowing down the-pump results in a permanently elevated level in the muscle, which may be the mechanism of the long-term inotropic effect of cardiac glycosides such as digoxin.
24.
Intravenous injection of pilocarpine to induce bronchospasm was followed by intravenous injection of the agonists . Arrangement of all amines according to their bronchodilator effect yields a series from the most potent, isopropyl-adrenaline, via the approximately equipotent bodies adrenaline, propyl-adrenaline and butyl-adrenaline, to the weakly active inotropic effects.
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