In individual neurons, the high-conductance state is formally defined by the fact that the total synaptic conductance received by the neuron is larger than its natural resting ( or leak ) conductance, so in a sense the neuron is " driven " by its inputs rather than being dominated by its intrinsic activity.
22.
GDF3 is a bi-functional protein that has some intrinsic activity and also modulate other TGF-? superfamily members, e . g . potentiates the activity of NODAL . It may also inhibit other TGF-? superfamily members ( i . e . definitive endoderm formation during the pre-gastrulation stages of development.
23.
In 2007 the concept of the default mode was criticized as not being useful for understanding brain function, on the grounds that a simpler hypothesis is that a resting brain actually does more processing than a brain doing certain " demanding " tasks, and that there is no special significance to the intrinsic activity of the resting brain.
24.
Eptapirone and related high-efficacy 5-HT 1A full and super agonists such as befiradol and F-15, 599 were developed under the hypothesis that the maximum exploitable therapeutic benefits of 5-HT 1A receptor agonists might not be able to be seen without the drugs employed possessing sufficiently high intrinsic activity at the receptor.
25.
Relative to morphine, levorphanol lacks complete cross-tolerance and possesses greater intrinsic activity at the MOR . Levorphanol's exceptionally high analgesic efficacy in the treatment of neuropathy is also conferred by its action on serotonin and norepinephrine transporters, similar to the opioids tramadol and tapentadol, and mutually complements the analgesic effect of its NMDA antagonization.
26.
The song and band Europe appeared in a 2015 USA television commercial for GEICO insurance, playing in a lunchroom as a microwave oven's timer is counting down toward zero seconds; the script touts the intrinsic activity of the band, saying if you're Europe, " you love a final countdown : it's what you do ."
27.
The flaw in Clark's receptor-occupancy model was that it was insufficient to explain the concept of partial agonist lead to the development of agonist models of drug action by Ariens in 1954 and by Stephenson in 1956 to account for the intrinsic activity ( efficacy ) of a drug ( that is, its ability to induce an effect after binding ).
28.
Initially proposed in 1940, it was formulated in 1957 and states that " wherever development occurs it proceeds from a state of relative globality and lack of differentiation to a state of increasing differentiation, articulation, and hierarchic integration . " It is an example of an organismic theory based on the intrinsic activity of living systems and is parallel to Piaget s genetic epistemology both emphasizing a wholistic view of development.
29.
SERMs are competitive partial agonists of the ER . Different tissues have different degrees of sensitivity to and activity of endogenous estrogens, so SERMs produce estrogenic or antiestrogenic effects depending on the specific tissue in question as well as the percentage of intrinsic activity ( IA ) of the SERM . An example of a SERM with high IA and thus mostly estrogenic effects is chlorotrianisene, while an example of a SERM with low IA and thus mostly antiestrogenic effects is ethamoxytriphetol.
30.
"' 5-Fluoro-" N ", " N "-dimethyltryptamine "'( "'5-fluoro-DMT "') is a tryptamine derivative related to compounds such as 5-bromo-DMT and 5-MeO-DMT . Fluorination of psychedelic tryptamines either reduces or has little effect on 5-HT 2A / C receptor affinity or intrinsic activity, although 6-fluoro-DET is inactive as a psychedelic despite acting as a 5-HT 2A agonist ( cf . lisuride ), while 4-fluoro-5-methoxy-DMT is a much stronger agonist at 5-HT 1A than 5-HT 2A.
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