21. CENP-A associates with the centromere and is necessary for assembly of the kinetochore . 22. Therefore, the encoded protein is thought to be an important part of functional kinetochores . 23. DYNLT3 binds to BUB3, a spindle checkpoint protein is present on kinetochores at prometaphase. 24. The stabilization of kinetochore fibers requires the trimeric structure of clathrin in order to crosslink microtubules. 25. Numerous kinetochore targets of Aurora kinases have been determined in organisms ranging from yeast to man. 26. The NUP107-160 complex has been localized to kinetochores and plays a role in mitosis. 27. Plk1 associates with kinetochores during mitosis. 28. Zwint-1 is clearly involved in kinetochore function although an exact role is not known. 29. Lepidopteran chromosomes possess a localized kinetochore plate to which the spindle microtubules attach during cell division. 30. To clarify the terminology, each chromosome has two chromatids, and each chromatid has a kinetochore .
