21. In addition, patients usually show severe hyperventillation due to profound metabolic acidosis mostly related to lactic acidosis . 22. This mutation is associated with both CPEO and Mitochondrial encephalomyopathy, lactic acidosis , and stroke-like episodes ( MELAS ). 23. A second case with failure to thrive, developmental delay, lactic acidosis and severe encephalopathy was reported in 2014. 24. Resolution of lactic acidosis is observed in patients with E1 alpha enzyme subunit mutations that reduce enzyme stability. 25. Most people with MELAS have a buildup of lactic acid in their bodies, a condition called lactic acidosis . 26. In rare cases, Glucovance may cause lactic acidosis , which can be fatal in up to half of the cases. 27. Lactic acidosis , a potentially life-threatening buildup of lactic acid in the body, may also occur due to mitochondrial toxicity.28. The excess hydrogen cations produced during lactic acidosis are widely believed to actually derive from production of lactic acid. 29. Females with residual pyruvate dehydrogenase activity will have no uncontrollable systemic lactic acidosis and few, if any, neurological symptoms. 30. It is expected that most cases will be of mild severity and have a clinical presentation involving lactic acidosis .
