However, at the lagging strand, DNA polymerase ? needs to be continually loaded at the start of each Okazaki fragment.
22.
Since replication occurs in opposite directions at opposite ends of parent chromosomes, each strand is a lagging strand at one end.
23.
In these plots, a positive deviation from C corresponds to lagging strand and negative deviation from C corresponds to leading strand.
24.
During normal DNA replication, the polymerase on the lagging strand is required to unclamp and re-clamp the replication region continuously.
25.
Consider the following : the helicase continuously unwinds the parental duplex, but the lagging strand must be polymerised in the opposite direction.
26.
This 3'addition provides a template for extension of the 5'end of the daughter strand by lagging strand DNA synthesis.
27.
DNA-binding proteins that rapidly reassociate post-replication prevent Pol? from repairing errors produced by Pol? in the mature lagging strand.
28.
There is a richness of guanine over cytosine and thymine over adenine in the leading strand and vice versa for the lagging strand.
29.
Originally, this asymmetric nucleotide composition was explained as a different mechanism used in DNA replication between the leading strand and lagging strand.
30.
It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes.
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