Chun Kim et al . showed how anthrax, which produces a metalloprotease Lethal Factor ( LF ) protein to target MAPKK, is vulnerable to human neutrophil protein-1 ( HNP-1 ).
22.
Cutaneous anthrax is rarely fatal if treated, because the infection area is limited to the skin, preventing the lethal factor, edema factor, and protective antigen from entering and destroying a vital organ.
23.
The protective antigen proteins assemble in clusters of seven, forming a barrel-shaped structure with a docking site for either edema factor or lethal factor, the other two members of the toxic troika.
24.
To enter the cells, the edema and lethal factors use another protein produced by " B . anthracis " called protective antigen, which binds to two surface receptors on the host cell.
25.
The other advance reported Tuesday was the determination of the exact three-dimensional structure of the lethal factor, the component of anthrax toxin that is injected into certain cells of the immune system.
26.
By employing molecular biology methods combined with the new genome sequencing information and bioinformatics, they discovered a new toxin ( sibling lethal factor ), which acts selectively only on the same bacterial strain.
27.
The discovery of lethal factor's structure should enable scientists to design molecules that can grab onto the protein and disable it, said Robert Liddington of The Burnham Institute, an author of the paper.
28.
By working out the exact anatomy of the lethal factor, Liddington has provided the information required by drug designers to synthesize small chemicals that will interact with the lethal factor and block its function.
29.
By working out the exact anatomy of the lethal factor, Liddington has provided the information required by drug designers to synthesize small chemicals that will interact with the lethal factor and block its function.
30.
The lethality of the anthrax disease is due to the bacterium's two principal virulence factors : the protein components : protective antigen ( PA ), edema factor ( EF ), and lethal factor ( LF ).
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