21. Another example is the schizophrenia-linked gene MTHFR, with murine knockouts showing decreased levels of reelin in the cerebellum. 22. Venter himself recognized his own ADHD behavior in his adolescence, and later found ADHD-linked genes in his own DNA. 23. Even when patients with mutations in X-linked genes ( MECP2 and FMR1 ) are excluded, the gender bias remains. 24. Hirsch cites the newly detected fat-linked gene as an example of how primitive understanding is of a trait like obesity. 25. Beutler immediately recognized that this might account for the variable expression of X-linked genes in females heterozygous for X-linked mutations. 26. In this genome-wide survey, the scientists found that autosomal genes are more likely to undergo nonsense-mediated decay than X-linked genes . 27. Other linked genes include the Hereditary Prostate cancer gene 1 ( HPC1 ), the androgen receptor, and the vitamin D receptor. 28. No person with Aicardi syndrome is known to have transmitted the X-linked gene responsible for the syndrome to the next generation. 29. Typically PDH is the result of a mutation in the X-linked gene for the E1 subunit of the pyruvate dehydrogenase complex. 30. The first step involves mutation in modifier genes that regulate a complex cluster of linked genes that cause large changes in morphology.
