In juvenile ferret lymphosarcoma, large, immature lymphocytes ( lymphoblasts ) rapidly invade the thymus or the organs of the abdominal cavity, particularly the liver and spleen.
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Normally lymphoblasts are found in the bone marrow, but in acute lymphoblastic leukemia ( ALL ), lymphoblasts proliferate uncontrollably and are found in large numbers in the peripheral blood.
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Normally lymphoblasts are found in the bone marrow, but in acute lymphoblastic leukemia ( ALL ), lymphoblasts proliferate uncontrollably and are found in large numbers in the peripheral blood.
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A range of leukocytes can be involved, including lymphocytic cell lines such as large lymphocyte, lymphoblast, primitive reticular cells, and occasional plasma cells, as well as macrophage and plasma cells.
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The B lymphocyte differentiation and maturation pathway that eventually generate IgE-secreting plasma cells go through the intermediate steps of IgE-expressing B lymphoblasts and involves the interaction with IgE-expressing memory B cells.
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Naive lymphocytes ( those with no history of contact with antigens ) travel from the bone marrow or high endothelial venules of the thymus where they develop as lymphoblasts, to lymph nodes, where they mature.
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Tanox, a biotech company based in Houston, Texas, proposed in 1987 that by targeting membrane-bound IgE ( mIgE ) on B lymphoblast and memory B cells, those cells can be lysed or down-regulated, thus achieving the inhibition of the production of antigen-specific IgE and hence a shift of immune balance toward non-IgE mechanisms.
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