Yet there is evidence that more than 80 % of the somatic mutations found in mutator phenotype human colorectal tumors occur before the onset of terminal clonal expansion.
22.
Mutator alleles can also evolve more easily when they only increase mutation rates in nearby DNA sequences, not across the whole genome : this is known as a contingency locus.
23.
Recognizing mismatches and repairing them is important for cells because failure to do so results in microsatellite instability ( MSI ) and an elevated spontaneous mutation rate ( mutator phenotype ).
24.
:As regards to the inducing mutation example, have a look at genetic hitchhiking, I believe it explains a mechanism by which a mutator gene could selfishly propagate itself.
25.
Recognizing those mismatches and repairing them is important for cells because failure to do so results in microsatellite instability ( MSI ) and an elevated spontaneous mutation rate ( mutator phenotype ).
26.
In the movie's cleverest sequence, he equips the Mutator with a video camera and sends it bouncing across the street into a neighbor's house to photograph the criminals.
27.
A time based constraint would look like : within each time window of duration " T ", mutator threads should be allowed to run at least for " Tm " time.
28.
The Governor decrees that the Doctor and Jondar will be executed by hanging, while Peri and Areta are to be subjected to undergo horrific scientific experiments at the hands of Quillam and his cell mutator.
29.
In the mid-1970s Dijkstra ( together with other authors ) introduced two useful abstractions ( mutator and collector ) to the study of tri-color marking " that is basic to incremental garbage collection.
30.
The four then escape back into the depths of the Punishment Dome towards a possible escape route before Peri, still in a stupor after the effects of the mutator, is recaptured and taken to the control centre.
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