21. However, there are possible strategies that may potentially " remyelinate " myelin sheaths in MS. 22. The oligodendrocytes that originally formed a myelin sheath cannot completely rebuild a destroyed myelin sheath. 23. This discovery later led Ranvier to careful histological examination of myelin sheaths and Schwann cells. 24. Oligodendrocytes are responsible for the creation of myelin sheaths . 25. The oligodendrocytes that originally formed a myelin sheath cannot completely rebuild a destroyed myelin sheath . 26. In multiple sclerosis, an inflammatory, Th1-type response destroys proteins in the myelin sheath that covers nerves. 27. The axon is insulated by a myelin sheath . 28. The newly formed myelin sheaths are thinner and often not as effective as the original ones. 29. BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. 30. He performed research of nerve fibers and the myelin sheath , and conducted studies involving connective tissue.