21. They are pathognomic foci of fibrinoid necrosis found in many sites, most often the myocardium . 22. His own work led to greater understanding of the cellular mechanisms underlying ischaemic and failing myocardium . 23. Electrical activity in the normal human heart begins when a cardiac action potential arises in the myocardium . 24. This process protects the myocardium , or heart muscle, from damage during the period of ischemia. 25. This increases the susceptibility of the myocardium to Early Afterdepolarizations ( EADs ) at low heart rates. 26. However, as heart disease progresses, significant upregulation of galectin-3 occurs in the myocardium . 27. This persistently stresses the heart and increases the workload of the lasting myocardium as measured by MVO2. 28. This causes the myocardium to work more efficiently, with optimized hemodynamics and an improved ventricular function curve. 29. The knockout mice also had increased triglyceride levels in the myocardium , which is a detrimental disease phenotype. 30. Tagged CNCCs were concentrated in the cardiac outflow tract, and some were found in the ventricular myocardium .
