Generalized seizures occur in various seizure syndromes, including myoclonic epilepsy, familial neonatal convulsions, childhood absence epilepsy, absence epilepsy, infantile spasms ( West's syndrome ), Juvenile Myoclonic Epilepsy and Lennox-Gastaut syndrome.
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Generalized seizures occur in various seizure syndromes, including myoclonic epilepsy, familial neonatal convulsions, childhood absence epilepsy, absence epilepsy, infantile spasms ( West's syndrome ), Juvenile Myoclonic Epilepsy and Lennox-Gastaut syndrome.
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Diseases caused by mutation in the mtDNA include Kearns-Sayre syndrome, MELAS syndrome, Leber's hereditary optic neuropathy, myoclonic epilepsy with ragged red fibers ( MERRF ), and others are due to point mutations in mtDNA.
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Less serious examples are benign rolandic epilepsy ( 2.8 per 100, 000 ), childhood absence epilepsy ( 0.8 per 100, 000 ) and juvenile myoclonic epilepsy ( 0.7 per 100, 000 ).
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Mutations in " SCARB2 " have also been shown to cause Gaucher disease and myoclonic epilepsy, as LIMP-2 is critical for the proper sorting and targeting of glucocerebrosidase enzyme ( the enzyme deficient in Gaucher disease ) to lysosomes.
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A mutation in " EFHC2 " which results in a serine to a tyrosine substitution at amino acid position 430 ( S430Y ) has been associated with juvenile myoclonic epilepsy in a male, German population . however, these findings remain controversial.
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However, lamotrigine has a broader clinical spectrum of activity than phenytoin and carbamazepine and is recognised to be protective against generalised absence epilepsy and other generalised epilepsy syndromes, including primary generalised tonic clonic seizures, juvenile myoclonic epilepsy, and Lennox-Gastaut syndrome.
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For an example of these issues see Talk : Myoclonic epilepsy # Big problems with this article where student edits would have been scored very highly on the above assessments but in fact had extensive copyvios, duplicated existing better material or were completely off-topic.
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When used in the treatment of myoclonic epilepsies such as juvenile myoclonic epilepsy, lower doses ( and lower plasma levels ) are usually needed, as even moderate doses of this drug can induce seizures, including tonic-clonic seizures, which can develop into status epilepticus, which is a medical emergency.
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When used in the treatment of myoclonic epilepsies such as juvenile myoclonic epilepsy, lower doses ( and lower plasma levels ) are usually needed, as even moderate doses of this drug can induce seizures, including tonic-clonic seizures, which can develop into status epilepticus, which is a medical emergency.
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