21. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. 22. Myostatin, a TGF-beta superfamily member, is a negative regulator of muscle growth. 23. AIP is the cellular negative regulator of the hepatitis B virus ( HBV ) X protein. 24. There have been very few interactions reported between RhoG and negative regulators of G protein function. 25. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. 26. Hence LINGO1 functions as a negative regulator of neuronal survival, axonal regeneration and oligodendrocyte differentiation. 27. "' Blosozumab "'binds SOST, a negative regulator of osteoblast activity. 28. The PspA / IM30 family is a negative regulator of sigma54 transcription initiation factor in bacteria. 29. VIVID is a negative regulator of light responses, although its mechanism is not yet known. 30. SOCS1, SOCS3 and CIS are also expressed which act as negative regulators of the cytokine signal.
