In addition, some carbamates are used in human pharmacotherapy, for example, the acetylcholinesterase inhibitors neostigmine and rivastigmine, whose chemical structure is based on the natural alkaloid physostigmine.
22.
Neostigmine methylsulfate, an anticholinesterase agent, has been used to target ChAT . In particular, use of neostigmine methylsulfate has been shown to have positive effects against congenital myasthenic syndrome.
23.
Neostigmine methylsulfate, an anticholinesterase agent, has been used to target ChAT . In particular, use of neostigmine methylsulfate has been shown to have positive effects against congenital myasthenic syndrome.
24.
Sugammadex, unlike neostigmine, does not inhibit acetylcholinesterase so cholinergic effects are not produced and co-administration of an antimuscarinic agent ( glycopyrronium bromide or atropine ) is not needed.
25.
Bowel movements may be stimulated by prescribing lactulose, erythromycin or, in severe cases that are thought to have a neurological component ( such as Ogilvie's syndrome ), neostigmine.
26.
Neostigmine can induce generic ocular side effects including : headache, brow pain, blurred vision, phacodonesis, pericorneal injection, congestive iritis, various allergic reactions, and rarely, retinal detachment.
27.
A Cochrane review on sugammadex concluded that " sugammadex was shown to be more effective than placebo ( no medication ) or neostigmine in reversing muscle relaxation caused by neuromuscular blockade during surgery and is relatively safe.
28.
In cases where death seemed imminent, the poisoning in sheep could be counteracted by the i . v . administration of neostigmine and atropine, whereas poisoning in calves was reversed by the administration of physostigmine.
29.
Pralidoxime is only effective in organophosphate toxicity ( i . e . it does not have an effect if the acetylcholinesterase enzyme is carbamylated, as occurs with neostigmine, physostigmine, or insecticides such as carbaryl ).
30.
Given that the toxins alter acetylcholine transmission which causes the paralysis, some patients have been successfully treated with cholinesterase inhibitors, such as physostigmine or neostigmine, but success is variable and may be species-dependent, as well.
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