Further confusion arose in 1980 1981, when there was a long debate in the pages of " neutral mutation.
22.
If nearly neutral mutations are common, then the proportion for which P _ { fix } is dependent on N _ e
23.
Neutral mutation and the neutral theory of molecular evolution are not separate from natural selection but add to Darwin's original thoughts.
24.
"Non-Darwinian Evolution " generated considerable interest in neutral mutations, and became very influential in the field of molecular evolution.
25.
Lewontin and Hubby's paper also discussed the possible explanation of the high levels of variability by either balancing selection or neutral mutation.
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While natural selection may encourage adaptation to a changing environment, neutral mutation may push divergence of species due to nearly random genetic drift.
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Over longer periods of time, neutral mutation and genetic drift causes the population to spread out over a larger neutral network in genotype space.
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For example, genetic drift could cause a nearly neutral mutation to become the dominant allele in a population by wiping out the wild type.
29.
In response, the mutation rate of nearly neutral mutations is reduced because these mutations are restricted to the tail of the distribution of selection coefficients.
30.
In this experiment it was shown that the overall DFE is bimodal, with a cluster of neutral mutations, and a broad distribution of deleterious mutations.
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