There is some evidence that very low doses of opioid antagonists such as naltrexone reduce the severity of opioid withdrawal.
22.
Unlike some other opioids and opioid antagonists, buprenorphine binds only weakly to and possesses little if any activity at the sigma receptor.
23.
Intravenous naloxone or nalmefene, quick-acting opioid antagonists, are the first-line treatment to reverse respiratory depression caused by an overdose of opium tincture.
24.
On January 26, 2015, Walkinshaw introduced HB 1671, to increase access to opioid antagonists in order to reduce deaths resulting from drug overdose.
25.
According to a Cochrane Collaboration review, the opioid antagonist naltrexone has short-term efficacy treating alcoholism, but evidence of longer term efficacy is lacking.
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If too large a dose of the opioid antagonist is given to a dependent patient, it will result in withdrawal symptoms ( possibly severe ).
27.
Additionally, substitution of certain very bulky groups on carbon 6 converts naloxone into a peripherally-selective opioid antagonist with no centrally-selective antagonist properties ( naloxegol ).
28.
And as doctors refrain from drastic changes in dose and provide post-injection monitoring, overdoses are rare and can be quickly treated with opioid antagonists like Naloxone.
29.
Certain medications including opioid antagonists such as naltrexone have been shown to be effective in the treatment of alcoholism, although research has not yet demonstrated long-term efficacy.
30.
At high doses, it exhibits analgesic activity which is not fully reversed by opioid antagonists, suggesting that the drug has both opioid and non-opioid mechanisms of action.
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