21. Porcine zona pellucida has its critics. 22. PZP stands for porcine zona pellucida . 23. Currently, zona drilling using a laser is the predominant method of opening the zona pellucida . 24. Filled with uterine fluid, the blastocyst breaks out of the zona pellucida and undergoes implantation. 25. Once the sperm cells find their way past the zona pellucida , the cortical reaction occurs. 26. ZP3 is the receptor in the zona pellucida which binds sperm at the beginning of fertilization. 27. Finally, while there has been ovarian pathogenesis found in some trials using zona pellucida vaccines, 28. In mammals, however, the extracellular matrix modified by the cortical reaction is the zona pellucida . 29. ZP3, a glycoprotein in the zona pellucida , is responsible for egg / sperm adhesion in mice. 30. The zona pellucida ( ZP ) is a specialized extracellular matrix that surrounds the oocyte and early embryo.