At present, it is still uncertain what fraction of normal pentamer contains J chain, and to this extent it is also uncertain whether a J chain-containing pentamer contains one or more than one J chain.
22.
However, it was subsequently found that IgM is able to polymerize in the absence of J chain as both a pentamer and a hexamer, however, both of these exist to lesser numbers in organisms lacking J chains.
23.
Refinements to the electron microscopy in 2007 allowed finding that the portal is a twelve ( 12 )-unit polymer present at one of the twelve capsid vertices instead of the U L-19 pentamer found at non-portal vertices.
24.
The minimal requirement to produce a GABA-gated ion channel is the inclusion of both ? and ? subunits, but the most common type in the brain is a pentamer comprising two ?'s, two ?'s, and a ? ( ? 1 ? 2 ? 2 ).
25.
A shared feature of these proteins is to bind only to a subclass of the known AREs that contain the pentamer AUUUA . A convergent effort of several research teams now adds CUGBP1 ( CUG binding protein 1 ) to the short list of ARE-Binding proteins that control mRNA stability, with the peculiarity that it binds to non-AUUUA AREs.
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