21. It has been consistently demonstrated that the plasma concentration of IL-6 increases during muscular exercise. 22. Highest blood plasma concentrations are reached after one hour. 23. Argatroban is given intravenously and drug plasma concentrations reach steady state in 1 3 hours. 24. These reductions are probably caused by reduced absorption and lower plasma concentrations of the carrier, LDL. 25. In humans, the nitrate action of nicorandil dilates the large coronary arteries at low plasma concentrations . 26. Consequently, the plasma concentration of homocysteine falls as the intracellular concentration of vitamin B 12 rises. 27. Plasma concentrations increased rapidly and peaked at 1 hour after the dose, independent of dose size.28. At higher plasma concentrations , both inhibitory and excitatory pathways are inhibited, causing CNS depression and potentially coma. 29. Absolute bioavailability is 58 %, and highest blood plasma concentrations of ixazomib are reached after one hour. 30. HCQ can increase plasma concentrations of penicillamine which may contribute to the development of severe side effects.
