21. However, as gap junctions breakdown, plasma proteins are able to enter the brain extracellular matrix. 22. Red blood cells, platelets, and plasma proteins cannot pass through the walls of the capillaries. 23. The majority of carvedilol is bound to plasma proteins ( 98 % ), mainly to albumin. 24. The resulting mixture that does pass through is, in essence, blood plasma without the plasma proteins . 25. Ivacaftor is approximately 99 % bound to plasma proteins , primarily to alpha 1-acid glycoprotein and albumin. 26. The plasma protein is a single chain polypeptide with an apparent molecular mass of 42 kiloDaltons. 27. Clonazepam is largely bound to plasma proteins . 28. The acid metabolite has a plasma protein binding of 87 %, and the alcohol of 15 %. 29. Aventis Behring focuses on blood plasma proteins . 30. AFP is a major plasma protein produced by the yolk sac and the liver during fetal development.