21. Interestingly, injection of tissue plasminogen activator ( a fibrinolytic drug ) in the CSF improved glymphatic functioning. 22. Both the activation of factor XIII by thrombin and plasminogen activator ( t-PA ) are catalyzed by fibrin. 23. Tissue-type plasminogen activator ( tPA ) is a serine proteinase that transforms plasminogen into its activated form, plasmin. 24. TPA ( tissue plasminogen activator ) and streptokinase are the two main clot-busting drugs, also known as thrombolytics. 25. Some associated cortical granule proteinases are the trypsin-like proteinase, ZP2 proteinase, and tissue-type plasminogen activator ( tPA ). 26. Plasminogen activator inhibitor-2 ( SerpinB2 ) has been reported to bind a series of intracellular and extracellular proteins.27. To migrate, endothelial cells need collagenases and plasminogen activator to degrade the clot and part of the ECM. 28. Another clot-dissolving enzyme that works faster and is more specific is called tissue plasminogen activator ( tPA ). 29. A good example of folding enhancement by periplasmic expression is the disulfide bond-containing plasminogen activator variant ( rPA ). 30. The pair plan to mix a drug called a tissue plasminogen activator into the saline solution within the probe.
