"Note : Many sources misrepresent the pace of follicle growth, some even suggesting that it takes only fourteen days for a primordial follicle to become preovulatory.
22.
The follicles have developed from primordial follicles, but the development has stopped ( " arrested " ) at an early antral stage due to the disturbed ovarian function.
23.
In regular intervals coinciding with each estrous cycle ( after puberty, of course ), a number of these primordial follicles start to develop in a process called folliculogenesis.
24.
During post-pubescent follicular development, and over the course of roughly a year, primordial follicles that have begun development undergo a series of critical changes in character, both histologically and hormonally.
25.
By day 36, primordial follicles occupy a narrow peripheral region of the ovarian cortex, while the rest of the cortical tissue is composed of degenerate primordial follicles, anovular cords and epitheloid cells.
26.
By day 36, primordial follicles occupy a narrow peripheral region of the ovarian cortex, while the rest of the cortical tissue is composed of degenerate primordial follicles, anovular cords and epitheloid cells.
27.
At 17 days, primordial follicles, each of consists of a small oocyte ( with no zona pellucida ) and a single layer of flattened pre-granulosa cells, can first be observed in the cortical layer of the ovary.
28.
At 18 22 weeks post-conception, the cortex of the female ovary contains its peak number of follicles ( about 4 to 5 million in the average case, but individual peak populations range from 6 to 7 million;'These " primordial follicles " contain immature oocytes surrounded by flat, squamous granulosa cells ( the support cells ) that are segregated from the oocyte's environment by the basal lamina.
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