21. Patients with von Willebrand disease typically display a normal prothrombin time and a variable prolongation of partial thromboplastin time. 22. Factor Va also decreases the Km of the reaction by enhancing the binding of prothrombin to the prothrombinase complex. 23. For a prolonged prothrombin time, vitamin K or fresh frozen plasma may be administered to reduce bleeding risk. 24. Therefore TEM is not meant to replace laboratory assays such as prothrombin time ( PT ) or factor assays. 25. Many analysers are capable of measuring a " derived fibrinogen " level from the graph of the Prothrombin time clot. 26. Traditional models of coagulation developed in the 1960s envisaged two separate cascades, the extrinsic prothrombin ( Factor II ). 27. Spontaneous specific inhibitors against clotting factors occur ( i . e . not in prothrombin complex concentrates to stop the bleeding. 28. Prothrombin activator is released in the body by a cascade of chemical reactions in response to damage in a blood vessel.29. Seratrodast has no effect on prothrombin time and activated partial thromboplastin time, thus ruling out any action on blood coagulation cascade. 30. A check can exclude deficiencies in iron, calcium, prothrombin time, vitamin B-12, vitamin D, and thiamine.
