In both haemophilia A and B, there is spontaneous bleeding but a normal bleeding time, normal prothrombin time, normal thrombin time, but prolonged partial thromboplastin time.
22.
The tissue factor ( extrinsic ) pathway is initiated by release of tissue factor ( a specific cellular lipoprotein ), and can be measured by the prothrombin time ( PT ) test.
23.
Notably, when one examines the lab values in Vitamin K deficiency [ see below ] the prothrombin time is elevated, but the partial thromboplastin time is normal or only mildly prolonged.
24.
Other tests performed in any patient with bleeding problems are a complete blood count ( especially platelet counts ), activated partial thromboplastin time, prothrombin time, thrombin time, and fibrinogen level.
25.
The classical coagulation tests such as PT ( prothrombin time ), aPTT ( activated partial thromboplastin time ) or thrombin time are not very sensitive for hyperfibrinolysis, and influenced by numerous other variables.
26.
Rare adverse effects ( < 2 % ) include : swelling, pain, and irritation at injection site, anorexia, jaundice, hepatic dysfunction, pruritus, acute pancreatitis, and increased prothrombin time.
27.
Severe cases are characterized by either obtundation ( dulled consciousness ) or the combination of elevated bilirubin levels and prolonged prothrombin time; the mortality rate in both severe categories is 50 % within 30 days of onset.
28.
Disseminated intravascular coagulation, another complication of rhabdomyolysis and other forms of critical illness, may be suspected on the basis of unexpected bleeding or abnormalities in hematological tests, such as a decreasing platelet count or prolongation of the prothrombin time.
29.
:References about INR include : Point-of-care international normalized ratio ( INR ) monitoring devices . . ., An Unpdate on INR Monitoring and Blood Clotting : INR . The latter states that INR was devised in 1983 as a ratio of prothrombin times
30.
Notably, the prothrombin time ( or international normalized ratio, INR ) used to test the effect of coumadins is highly dependent on factor VII, which explains why patients can have a therapeutic INR ( indicating good anticoagulant effect ) but still be in a hypercoagulable state.
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