Concurrent use of diuretics that inhibit the uptake of sodium by the distal tubule ( e . g . thiazides ) is hazardous and should be avoided because this can cause increased resorption of lithium in the proximal convoluted tubule, leading to elevated, potentially toxic levels.
22.
Under normal conditions in the proximal convoluted tubule of the kidney, most of the carbonic acid ( H 2 CO 3 ) produced intracellularly by the action of carbonic anhydrase quickly dissociates in the cell to bicarbonate ( ) and an ion ( a proton ), as previously mentioned.
23.
As a result, the filtrate leaving the Bowman's capsule is very similar to blood plasma ( filtrate or glomerular filtrate is composed of blood plasma minus plasma protein i . e . it contains all the components of blood plasma except the proteins ) in composition as it passes into the proximal convoluted tubule.
24.
The device s design requirements would require the filtration fraction in the glomerulus to vary between 15 %-20 %, or the filtration reabsorption in the proximal convoluted tubule to vary between 65 %-70 %, and finally the urea concentration in urine ( collected at one of the two outlets of the device ) to vary between 200-400mM.
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