21. Common sources are phosphoenol pyruvate , acetyl phosphate, and creatine phosphate. 22. The first four MCT isoforms are responsible for pyruvate / lactate transport. 23. It is converted into fumarate and pyruvate by 3-fumarylpyruvate hydrolase. 24. It activates pyruvate dehydrogenase phosphatase which in turn activates the pyruvate dehydrogenase complex. 25. It activates pyruvate dehydrogenase phosphatase which in turn activates the pyruvate dehydrogenase complex. 26. Serine is then converted to pyruvate by serine dehydratase. 27. The areas surrounding the phosphorylation sites on pyruvate dehydrogenase are shown in red. 28. Here, it is decarboxylated to produce and pyruvate . 29. Pyruvate carboxylase deficiency is an inherited metabolic disorder where anaplerosis is greatly reduced.30. Mutations in the " PC " gene cause pyruvate carboxylase deficiency.
