Tyrosine Y701 functions similarly to tyrosine Y567 in the RB69 bacteriophage orthologue as the sugar steric gate that prevents ribonucleotide incorporation.
22.
In her current research, Stubbe continues to study the function of ribonucleotide reductases and the mechanisms of clinically useful drugs.
23.
6-MP ribonucleotide inhibits purine nucleotide synthesis and metabolism by inhibiting an enzyme called Phosphoribosyl pyrophosphate amidotransferase ( PRPP Amidotransferase ).
24.
The Adenine Riboswitch selectively recognizes adenine, and contains a uracil ribonucleotide in position 74 of the adenine-binding aptamer domain.
25.
The Guanine Riboswitch selectively recognizes guanine, and contains a cytosine ribonucleotide in position 74 of the guanine-binding aptamer domain.
26.
It primarily inhibits the enzyme thymidylate synthase, but also has effects on DHFR, aminoimidazole carboxamide ribonucleotide formyltransferase and glycinamide ribonucleotide formyltransferase.
27.
It primarily inhibits the enzyme thymidylate synthase, but also has effects on DHFR, aminoimidazole carboxamide ribonucleotide formyltransferase and glycinamide ribonucleotide formyltransferase.
28.
Dehydration of FGAM by enzyme FGAM cyclase results in the closure of the imidazole ring, as 5-aminoimidazole ribonucleotide ( AIR ).
29.
The systematic name of this enzyme class is "'urate-ribonucleotide : phosphate alpha-D-ribosyltransferase " '.
30.
These ribonucleotide changes are likely to be harmful, as their ribose 2-hydroxyl group increases susceptibility of the adjacent phosphodiester bond to hydrolysis.
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