21. So a statment like " Rotenone causes Parkinson's Disease " is misleading. 22. The major active ingredients are rotenone and deguelin. 23. Derris root, when crushed, releases rotenone . 24. A rotenone treatment was applied in 2009 in an effort to remove brown bullhead catfish 25. Apparently, the killer ingredient is the natural insecticide rotenone , which occurs in plants. 26. Rotenone is also widely used in liquid form by fishery managers to destroy pest species.27. Deliberate ingestion of rotenone can be fatal. 28. Because of these developments, rotenone was investigated as a possible Parkinson-causing agent. 29. Like MPP +, rotenone also interferes with complex I of the electron transport chain. 30. So Rotenone causes Parkinson's Disease by lowering dopamine levels . [ 12 ]"
