Awards came early to the partners from the American Institute in 1867 and the Centennial Exposition of 1876 in Philadelphia whose first product, santonin, neatly combined the skill of Erhart, the confectioner, with that of his cousin, the chemist.
22.
According to the US Pharmacopoeia, santonin occurs " in colorless, shining, flattened, prismatic crystals, odorless and nearly tasteless when first put in the mouth, but afterward developing a bitter taste; not altered by exposure to air, but turning yellow on exposure to light.
23.
Dosage forms varied for santonin; in the 19th-20th centuries, santonin lozenges or suppositories designed for single-dosage treatment of ascarid infestation were the typical form of treatment, whilst in the 50's the two remaining santonin preparations on the market in the United States were liquid medications.
24.
Dosage forms varied for santonin; in the 19th-20th centuries, santonin lozenges or suppositories designed for single-dosage treatment of ascarid infestation were the typical form of treatment, whilst in the 50's the two remaining santonin preparations on the market in the United States were liquid medications.
25.
Dosage forms varied for santonin; in the 19th-20th centuries, santonin lozenges or suppositories designed for single-dosage treatment of ascarid infestation were the typical form of treatment, whilst in the 50's the two remaining santonin preparations on the market in the United States were liquid medications.
26.
The main reason for the challenge in determining how the secondary metabolite is produced is because ( + )-totarol does not follow the isoprene rule : the isopropyl group of ( + )-totarol is in the wrong place This hypothesis was motivated by the well known santonin-desmotroposantonin rearrangement of steroid dienones into aromatic compounds.
27.
Commercial preparations containing santonin ( usually containing a purgative laxative as well ) also appeared in US drug formularies as late as the'50s; the " Modern Drug Encyclopedia and Therapeutic Index " of 1955 listed Lumbricide ( produced by Massengill ) and a generic santonin preparation made by Winthrop-Stearns ( now Winthrop-Sanofi ).
28.
Commercial preparations containing santonin ( usually containing a purgative laxative as well ) also appeared in US drug formularies as late as the'50s; the " Modern Drug Encyclopedia and Therapeutic Index " of 1955 listed Lumbricide ( produced by Massengill ) and a generic santonin preparation made by Winthrop-Stearns ( now Winthrop-Sanofi ).
29.
Apart from his work on organic chemistry, which includes also an investigation of santonin, Cannizzaro rendered great service to chemistry with his 1858 paper " Sunto di un corso di Filosofia chimica ", or " Sketch of a course of chemical philosophy ", in which he insisted on the distinction, previously hypothesized by Avogadro, between atomic and molecular weights.
30.
Typically, santonin must be taken whilst fasting completely ( both before and after taking the drug ) for " single dose " regimens or on a full stomach with all fats and oils in the diet being avoided for 2 3 days before treatment as well as during treatment and 2 3 days afterwards ( due to santonin being fat soluble and having an increased risk of side effects ); after a course of santonin, a purgative must be given to cleanse the body of the dead worms . ( The two remaining registered santonin preparations in the United States as of 1955 were in fact santonin / purgative combinations; Lumbricide contained santonin and senna ( among other ingredients ) and the Winthrop-Stearns generic preparation was a santonin / cascara sagrada combination drug .)
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