21. In skeletal muscle it associates with the ryanodine receptor RyR1 of the sarcoplasmic reticulum via a mechanical linkage. 22. Increased cytoplasmic calcium concentrations cause increased calcium uptake into the sarcoplasmic reticulum ( SR ) via the SERCA2 transporter. 23. Unlike IP 3, IP 4 does not cause opening of calcium channels on the endoplasmic reticulum or sarcoplasmic reticulum . 24. Sarcalumenin is a calcium-binding protein that can be found in the sarcoplasmic reticulum of aerobic and anaerobic exercise activity. 25. However, lack of CD97 only affects the structure of the sarcoplasmic reticulum , but not the function of skeletal muscle. 26. When phospholamban is phosphorylated by its ability to inhibit the sarcoplasmic reticulum calcium pump ( SERCA ) is lost. 27. RYR1 functions as a sarcoplasmic reticulum, as well as a connection between the sarcoplasmic reticulum and the transverse tubule. 28. ITP3K is plays a role in the sarcoplasmic reticulum , resulting in an influx of calcium ions into the cytoplasm. 29. RYR1 functions as a sarcoplasmic reticulum , as well as a connection between the sarcoplasmic reticulum and the transverse tubule. 30. AF and TdP may be induced with L-type calcium channel hyperactivity and increased calcium release from the sarcoplasmic reticulum .
