With Paul Blocq he was the first to describe senile plaques and with Romanian neurologist Ion Minea confirmed in 1913 Hideyo Noguchi's discovery of " Treponema pallidum " in the brain in patients with general paresis.
22.
In an article written by Stone J . it was proposed that the formation of senile plaques is initiated by the bleeding from a cerebral capillary, which creates the conditions for the formation of an amyloid-rich plaque.
23.
Although three enzymes can process APP, only ?-( beta ) and ?-( gamma ) secretase are directly involved in the formation of senile plaques . ?-secretase ( BACE ) is a protease enzyme that cleaves proteins and peptides.
24.
Significant research has been done on Colostrinin s possible efficacy in Alzheimer's disease, the most common form of dementia The disease is characterized by extracellular senile plaques consisting mainly of aggregated amyloid-beta ( A?) and intracellular neurofibrillary tangles, containing the cytoskeletal protein tau.
25.
These fibrils deposit outside neurons in dense formations known as senile plaques or neuritic plaques, in less dense aggregates as " diffuse plaques ", and sometimes in the walls of small blood vessels in the brain in a process called amyloid angiopathy or congophilic angiopathy.
26.
Because the extracellular deposition of A? fibrils in senile plaques is not sufficient to predict risk or onset of AD, and clinical trials of drugs that target the A? fibrillization process have largely failed, the ion channel hypothesis provides novel molecular targets for continued development of AD therapies and for better understanding of the mechanism underlying onset and progression of AD.
27.
:: Hypomethylation has been observed in promoters of " presenilin 1 " ( Wang et al ., 2008 ), " GSK3beta ", which phosphorylates tau protein ( Nicolia et al ., 2010 ), and " BACE1 " ( Byun et al ., 2012 ), an enzyme that cleaves APP into the amyloid-beta form, which in turn aggregates into insoluble senile plaques.
28.
This repression of NEP could result in a feed-forward buildup of senile plaques; combined with the observed increase in AD brains of " BACE1-AS " and corresponding increases in BACE1 protein and amyloid beta ( Faghihi et al ., 2008; see above ), multiple levels of epigenetic regulation may be involved in controlling amyloid-beta formation, clearance or aggregation, and senile plaque deposition.
29.
This repression of NEP could result in a feed-forward buildup of senile plaques; combined with the observed increase in AD brains of " BACE1-AS " and corresponding increases in BACE1 protein and amyloid beta ( Faghihi et al ., 2008; see above ), multiple levels of epigenetic regulation may be involved in controlling amyloid-beta formation, clearance or aggregation, and senile plaque deposition.
30.
In his long activity as a psychiatrist and neurologist, Cerletti published 113 original papers, about the pathology of senile plaques in Alzheimer's disease, on the structure of neuroglia, the blood brain barrier, syphilis, etc . In 1950 he received an honorary degree by the Coll�ge de Sorbonne at the University of Paris, in addition to a long list of other awards and degrees.
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