Recently, the volumes of sexually dimorphic brain structures in transgender women were found to change and approximate typical female brain structures when exposed to estrogen concomitantly with androgen deprivation over a period of months, suggesting that estrogen and / or androgens have a significant part to play in sex differentiation of the brain, both prenatally and later in life.
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As Ellis & Cole-Harding ( 2001 ) outline, the chain of events in prenatal stress affecting brain sex differentiation appears to be that stress causes the mother's adrenal glands to release high levels of stress hormones into the blood system, substantial proportions of which cross the placental barrier and interfere with the fetus'production of sex hormones temporarily, most notably testosterone.
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