There is no data in the literature indicating that either approach is feasible " in vivo ", suggesting that these methods may result in permanent signal amplification.
22.
Therefore, a typical target-specific probe set ( containing 20 oligo pairs ) can generate 8, 000-fold signal amplification at the location of the target RNA.
23.
If the guess is wrong, the signal will be interfered destructively, resulting in a diminished output signal, but the correct guess will result in the signal amplification described above.
24.
Fidelity of analog signal amplification and filtering is usually critical and as a result, analog ICs use larger area active devices than digital designs and are usually less dense in circuitry.
25.
Chondrocytes have been shown to secrete TGF-b, and upregulate TGF-b receptors in response to mechanical stimulation; this secretion may be a mechanism for autocrine signal amplification within the tissue.
26.
Thus, the existence ( and magnitude ) of receptor reserve depends on the agonist ( efficacy ), tissue ( signal amplification ability ) and measured effect ( pathways activated to cause signal amplification ).
27.
Thus, the existence ( and magnitude ) of receptor reserve depends on the agonist ( efficacy ), tissue ( signal amplification ability ) and measured effect ( pathways activated to cause signal amplification ).
28.
Target-specific probes hybridize to each target RNA . Subsequent signal amplification is predicated on specific hybridization of adjacent probes ( individual oligonucleotides [ oligos ] that bind side by side on RNA targets ).
29.
This method is more sensitive than direct detection strategies because of signal amplification due to the binding of several secondary antibodies to each primary antibody if the secondary antibody is conjugated to the fluorescent or enzyme reporter.
30.
The total strength of signal amplification by a GPCR is determined by the lifetimes of the ligand-receptor complex and receptor-effector protein complex and the deactivation time of the activated receptor and effectors through intrinsic enzymatic activity.
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