21. *Subcortical aphasias characteristics and symptoms depend upon the site and size of subcortical lesion. 22. Cannon and Britton were doing research on emotional expression resulting from action of subcortical areas. 23. An increase in cortical and subcortical NGF has been found in patients with Alzheimer s disease. 24. Multiple cerebral ischemic events may lead to subcortical ischemic depression, also known as vascular depression. 25. Myoclonus dystonia has been characterized under subcortical origin, specifically under nonsegmented myoclonus or brainstem myoclonus. 26. Heath, in the 1950s, stimulated subcortical areas and made detailed observations of behavioral changes. 27. Shown in the accompanying figure is a subcortical template reconstruction from the population of MRI subjects. 28. Each had shown an increase in the activity of the basal ganglia, a subcortical brain structure. 29. But they make up the active elements of a vital subcortical system that choreographs activity throughout the brain. 30. Conversely, involuntary facial expressions are believed to be innate and follow a subcortical route in the brain.