21. With a high value, proton transfer in the transition state is almost complete. 22. One way that enzymatic catalysis proceeds is by stabilizing the transition state through electrostatics. 23. An example of the late transition state is bromination. 24. Transition state for the Narasaka Prasad reduction showing the reasons for the observed diastereoselectivity25. An example of the early transition state is chlorination. 26. Thus the energy of the transition state is mostly polarization energy of the solvent. 27. Correlation diagrams can then be used to predict the height of transition state barriers. 28. Transition state theory fails for some reactions at high temperature.29. The formation of this oxyanion hole stabilizes the transition state of the enzyme-catalyzed reaction. 30. Nonetheless, cyclic transition states are frequently invoked to interpret diastereoselectivity.
