21. In contrast, the mRNA encoding the Tropomyosin Br2 protein was excluded from the pole of the neuron. 22. In addition, elevated expression of Tropomyosin 4 has been linked with lymph node metastasis in breast cancer. 23. Intermicrovillous space is increases with contractile activity of myosin II and tropomyosin , and decreases when contraction ceases. 24. Specific functional insights into the function of the ?-tropomyosin isoform have come from studies employing transgenesis. 25. Thus, the tropomyosin -troponin complex again covers the binding sites on the actin filaments and contraction ceases. 26. Studies in colon and bladder cancer found increased expression of the LMW tropomyosin " Tropomyosin 5NM1 ". 27. Studies in colon and bladder cancer found increased expression of the LMW tropomyosin " Tropomyosin 5NM1 ". 28. This discovery has led to the development of novel anti-tropomyosin compounds as potential anti-cancer agents. 29. Cofilin also binds with other proteins such as myosin, tropomyosin , ?-actinin, gelsolin and scruin. 30. It is the tropomyosin -binding and thin filament anchoring subunit of the troponin complex in cardiac muscle cells.
