As positively charged polypeptides GFLs are unable to penetrate the blood brain barrier, and they have very small volume of distribution in the tissues.
22.
The Volume of distribution is 2.5-3.5 L / kg . 30-50 % is excreted unchanged in the urine.
23.
Half-life is determined by clearance ( CL ) and volume of distribution ( V D ) and the relationship is described by the following equation:
24.
The volume of distribution for lipophilic drugs may be greatly increased in the obese .-Nunh-huh 15 : 59, 24 May 2008 ( UTC)
25.
The pharmacokinetics of lamotrigine follow first-order kinetics, with a half-life of 29 hours and volume of distribution of 1.36 L / kg.
26.
Volume of distribution may be increased by renal failure ( due to fluid retention ) and liver failure ( due to altered body fluid and plasma protein binding ).
27.
In humans, the volume of distribution of pregabalin for an orally administered dose is approximately 0.56 L / kg and is not bound to plasma proteins.
28.
Carvedilol is a basic, hydrophobic compound with a steady-state volume of distribution of 115 L . Plasma clearance ranges from 500 to 700 mL / min.
29.
Individuals with liver impairment have a reduced volume of distribution as well as a reduced total clearance of clotiazepam; renal impairment does not affect the kinetics of clotiazepam.
30.
Acecainide has a volume of distribution of 1.5 L / kg that is less than the Vd of procinamide ( 2.0 L / kg ).
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