21. Because of their secretory function, these cells have many small granules of zymogens that are visible. 22. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen . 23. The enzyme is initially in an inactive precursor zymogen form, with an additional amino terminal peptide sequence. 24. "' Procarboxypeptidase "'is a precursor ( zymogen ) to the pancreatic enzyme carboxypeptidase. 25. The zymogen granules are the vesicles that store enzymes near the plasma membrane for easy release when stimulated. 26. The pancreas secretes zymogens partly to prevent the enzymes from digesting proteins in the cells in which they are synthesised. 27. Trypsinogen is normally created and stored an inactive zymogen of trypsin in the pancreas, but occasionally will autoactivate itself. 28. The precursor zymogens , are inactive variants of the enzymes; which avoids the onset of pancreatitis caused by autodegradation. 29. ABP molecules serve as probes to irreversibly bind only to active proteases and ignore their zymogen precursors and inhibited proteases. 30. This zymogen is activated by hydrochloric acid ( HCl ), which is released from parietal cells in the stomach lining.
