It delineates acanthosis nigricans syndromes according to their associated syndromes, including benign and malignant forms, forms associated with obesity and drugs, acral acanthosis nigricans, unilateral acanthosis nigricans, and mixed and syndromic forms.
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It delineates acanthosis nigricans syndromes according to their associated syndromes, including benign and malignant forms, forms associated with obesity and drugs, acral acanthosis nigricans, unilateral acanthosis nigricans, and mixed and syndromic forms.
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Acanthosis nigricans is a skin condition in which areas of the skin is of a dark and velvety discoloration, often seen in the body folds and creases such as the armpits, groin, and neck.
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A more intensive screening effort last year in the Rio Grande Valley area found that 17 to 27 percent of fourth-, fifth-and sixth-graders had the skin discoloration, known as acanthosis nigricans.
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Associated conditions include hyperuricemia, fatty liver ( especially in concurrent obesity ) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome ( in women ), erectile dysfunction ( in men ), and acanthosis nigricans.
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Pathomorphologic study of tissue sampling revealed : polymorphism of spiny epithelial cells has progressed into atypism; increased mitosis; giant and multinucleate cells; acanthosis; hyperkeratosis and parakeratosis; basal membrane and basal layer are retained.
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Alternatively, a more involved diagnostic test can be used directly at the first prenatal visit for a woman with a high-risk pregnancy . ( for example in those with polycystic ovarian syndrome or acanthosis nigricans ).
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In addition to obesity and a family history of the disease, researchers said, many develop a condition called acanthosis nigricans, dark, irregular folds of skin around the neck, under the arms or behind the knees.
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A skin abnormality known as acanthosis nigricans, which involves a discoloration ( hyperpigmentation ) and velvety thickening ( hyperkeratosis ) of the skin around skin fold regions of the neck, groin and under arms is also a common symptom.
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In some cases, paraneoplastic acanthosis nigricans ( 35 % of patients ), florid cutaneous papillomatosis, ichthyosis acquisita ( acquired hypertrichosis lanuginosa ), Cowden syndrome, tylosis, acrokeratosis paraneoplastica of Bazex and tripe palms accompanies the sign of Leser-Tr�lat.
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